SURFACE TENSION AND DILATION VISCOELASTICITY OF BLOOD SERUM IN PATIENTS WITH ISCHEMIC
HEART DISEASE, OPERATED IN THE CONDITIONS OF ARTIFICIAL BLOOD CIRCULATION 

Kuznetsova Irina Vadimovna, Doctor of medical sciences, professor, sub-department of anesthesiology, intencive care and emergency medicine, Donetsk National Medical University named after M. Gorky (16 Ilyicha avenue, Donetsk, Ukraine), E-mail: reanim@dsmu.edu.ua
Potapov Vladimir Vladimirovich, Postgraduate student, Donetsk National Medical University named after M. Gorky (16 Ilyicha avenue, Donetsk, Ukraine), E-mail: reanim@dsmu.edu.ua
Shramenko Ekaterina Konstantinovna, Doctor of medical sciences, associate professor, sub-department of anesthesiology, intencive care and emergency medicine, Donetsk National Medical University named after M. Gorky (16 Ilyicha avenue, Donetsk, Ukraine), E-mail: reanim@dsmu.edu.ua
Zenin Oleg Konstantinovich, Doctor of medical sciences, professor, sub-department of human anatomy, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: zen.olegz@gmail.com
Kuznetsov Aleksandr Sergeevich, Doctor of medical sciences, professor, head of cardio and X-ray vascular surgery unit, Donetsk Clinical Territorial Medical Association (14 Ilyicha avenue, Donetsk, Ukraine), E-mail: kouznetsov2@gmail.com 

[612.014.462.7+612.014.462.8]:611.018.54+616.12-009.72 

10.21685/2072-3032-2019-3-13 

Background. The aim of our research was to study surface tension and dilatation viscoelasticity of blood serum and plasma in patients with ischemic heart disease and valve cardiac pathology, who underwent operations with cardiopulmonary bypass.
Materials and methods. In 27 patients with ischemic heart disease, the average age 62,1±0,9, surgical interventions were performed with the aim of myocardial revascularization in cardiopulmonary bypass, the prospective study of surface tension and dilatation viscoelasticity of blood serum and plasma was performed. There were used the methods of drop and bubble form (Tensiometers PAT-1 and РАТ-2P SINTERFACE Technologies, Berlin, Germany).The blood for research was sampled an hour before operation, after 12 hours (1-st day) and in 7 days after operation. The rheological active markers (glucose, protein, albumen, urea and creatinine) were choose from routine biochemical parameters to evaluate.
Results. On the first day after operation it was revealed the statistically significant increase in glucose, urea, creatinine levels and statistically significant decrease in protein and albumen levels in both groups. The same time, changes in surface tension markers and viscoelastic modulus showed the significant increase of serum surface active substances. In 7 day, in the both groups, the positive dynamics in biochemical parameters was revealed, but viscoelastic modulus E (frequency 0,1–0,01 Hz) was statistically higher than before operation.
Conclusion. Pathological changes in biochemical markers which influence blood viscosity (glucose, protein, albumen, urea and creatinine) were accompanied by significant changes in surface tension and dilatation viscoelasticity of blood serum. The same time these biochemical markers are not the dominant predictors of the changes in blood rheology and viscosity. 

dilatation viscoelasticity, ischemic heart disease 

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